Associate Director Biostatistics

ProQR Therapeutics is a NASDAQ-listed biotechnology company headquartered in Leiden, the Netherlands with an office in and Cambridge, Massachusetts, USA. At ProQR, we are on a mission to edit RNA, treat disease and change lives. A team of 180+ enthusiastic ProQRians from all walks of life and more than 30 different nationalities is committed to pioneering transformative RNA therapies to make a difference in the lives of the communities we serve. Our proprietary Axiomer™ RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cells own editing machinery. Axiomer RNA editing technology harnesses ADAR (Adenosine Deaminase Acting on RNA), a protein which is present in all human cells, to repair G-to-A mutations, modulate protein, and enable protective mutation functions. Axiomer could potentially yield a new class of innovative medicines and treat currently untreatable diseases. By harnessing the power of RNA editing, we aim to create a world where genetics inform your health - but never limit it. Our Development / Clinical Quantitative Science department is currently looking for an Associate Director Biostatistics (Full-time) to join our team. Location: Leiden, the Netherlands (on-site). The Role As Associate Director Biostatistics, you will provide senior statistical leadership across clinical and translational programs. This is a hands-on, high-autonomy role with strong matrix leadership: you will shape quantitative strategy, guide study design and analysis, oversee complex computational work, and help teams make clear, evidence-based decisions. You will work closely with Clinical Development, Clinical Operations, Data Management, Biomarkers, Regulatory, external partners, CROs, and senior stakeholders. The role requires critical thinking, scientific maturity, strong communication, and the ability to operate pragmatically in a fast-moving biotech environment. What You Will Do Serve as biostatistical lead for clinical and translational projects, including protocol design, endpoints, estimands, sample size, SAPs, TLFs, interim/adaptive decisions, reporting, and regulatory responses. Develop and defend quantitative strategies using frequentist and Bayesian methods, simulation, leveraging external evidence, sensitivity analyses, and decision-focused interpretation. Plan, oversee, monitor, QC, and document demanding computational work, ensuring reproducibility, traceability, and fit-for-purpose quality. Contribute to clinical development strategy by translating biological, clinical, regulatory, and operational questions into robust statistical plans. Author and review statistical sections of protocols, synopses, briefing books, CSRs, regulatory documents, internal decision memos, and presentations. Oversee CROs, consultants, programmers, and analytical vendors to ensure timelines, quality, documentation, and audit readiness. Support GCP-aware ways of working and contribute…