Associate Director, Chemical Engineering

Associate Director, Chemical Engineering Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease. Position Description Nurix is seeking an experienced, independent, and highly motivated individual who will be accountable for end‑to‑end chemical engineering support of bexobrutideg (NX-5948) drug substance (DS) from late‑stage development through commercial launch, including oversight of external manufacturing sites. The Associate Director, Chemical Engineering will work closely with the CMC team and colleagues in cross-functional departments to provide scientific, technical, and hands-on leadership and oversight of facility and equipment operations at Contract Development Manufacturing Organizations (CDMOs) to support bexobrutideg drug substance manufacturing process optimization and scale-up. The position will report to the Director, Chemical Development. Responsibilities will include but are not limited to: Provide engineering leadership to design, develop and optimize scalable routes for small-molecule DS manufacturing, including demonstrated knowledge in unit operation design, process modeling, process equipment selection and scale-up methodologies. Review equipment configurations, qualification packages, and maintenance records at CDMOs to ensure equipment trains are properly qualified, maintained and operating at optimal performance to support Nurix manufacturing operations. Oversee equipment engineering and scale-up operations at DS CDMOs, including hands‑on process troubleshooting during engineering, clinical, registration and PPQ batches. Lead technology transfer to CDMOs including scale-up and demonstration of new chemical processes in development and commercial equipment. Coordinate with CDMOs and Nurix Quality Assurance, and Global Supply Chain functions to ensure timely manufacture and release of DS lots. Partner within Nurix CMC to drive process understanding (critical process parameters, critical quality attributes, control strategy) using engineering principles, DoE and QbD concepts. Review and approve Master Batch Records, campaign reports, deviation investigations and change controls for drug substance operations. Ensure manufacturing operations adhere to company quality, safety and regulatory standards (FDA, EMA, ICH, cGMP). Provide…