Associate Scientist II, MSAT

Company Overview: Strand Therapeutics is a clinical-stage biotechnology company pioneering programmable mRNA therapeutics to unlock the full potential of genetic medicines. Strand is applying its proprietary Signal Stack platform, which integrates EverScript circular RNA, AmpliScript self-replicating RNA, SignalPath targeted delivery, and logic-driven SignalLock genetic circuits to enable precise control of therapeutic activity across tissues and cell types and overcome foundational limitations in targeting, durability, and safety. Strand is advancing a pipeline with an initial focus on oncology and autoimmune disease. Its initial program, STX-001, an intratumorally delivered LNP-encapsulated self-replicating RNA expressing IL-12, has demonstrated preliminary evidence of systemic immune activation and anti-tumor activity in patients with advanced solid tumors who have progressed on prior therapies. Building on this early clinical validation, intravenously delivered STX-003 is designed for tumor-targeted expression and avoidance of off-target expression. STX-003, which is expected to enter the clinic in mid-2026, has the potential to be a major step forward for the fields of genetic medicine and oncology. Strand is also advancing STX-005, an in vivo CAR-T program designed to enable controlled, durable expression and repeat dosing. Founded by MIT synthetic biology pioneers, Strand has raised over $250 million and is headquartered in Boston, MA. Become the next standout single strand! Job Summary: Strand is looking for people who have the enthusiasm and motivation to be a highly contributing member of a small but extremely productive team. This opportunity will offer the employee the ability to work in a matrix-based environment and be a part of the future strategy of the company. We are looking for a highly motivated and innovative candidate for the role of Associate Scientist II of MSAT. The expectation is that the Associate Scientist II will have experience prior supporting preclinical and clinical-stage manufacturing processes within the gene and/or cell therapies space. Reporting to the Senior Scientist of MSAT, the right candidate will be a strategic thinker that brings a leadership presence and enthusiasm for Strand along with a desire to conquer new challenges. Primary Responsibilities: Support the execution, continuous improvement, and maturation of Strand’s preclinical and clinical-stage manufacturing processes. Perform lab-scale RNA and lipid nanoparticle production and analytical testing to evaluate process improvements, troubleshoot technology transfer and manufacturing challenges, improve process robustness, and support process scale-up. Author technical protocols and reports documenting experimental procedures, results, and conclusions. Collaborate with Process Development, Analytical Development, Automation, and Quality teams to advance Strand’s manufacturing programs. Partner with external technical…