Director / Senior Director, Program Management

About Tr1X Tr1X is a clinical-stage biotechnology company developing engineered Tr1 cell therapies to restore immune balance in autoimmune and inflammatory diseases. Leveraging the unique biology of Tr1 cells, the company is advancing a pipeline of off-the-shelf allogeneic and in vivo CAR-Tr1 therapies designed to deliver targeted immunoregulation and address diseases driven by immune dysfunction, including transplant-related complications. Founded by pioneers in the discovery of Tr1 cells, Tr1X, Inc. is focused on developing durable, potentially curative therapies for conditions with high unmet need. For more information, visit www.tr1x.bio . Position Summary The Director/Senior Director, Program Management provides strategic leadership and performs hands-on operational activities supporting cell therapy programs in autoimmune indications. This individual aligns cross-functional teams, manages dependencies and risks, and ensures programs deliver against milestones and organizational objectives. The Director/Senior Director partners closely with Clinical Development, Clinical Operations, Regulatory, Technical Operations and R&D, along with external partners to drive execution of complex preclinical and clinical programs from early development through registrational studies. Key Responsibilities Translate program strategy into integrated timelines, milestones, and deliverables, ensuring coordination across all contributing functions. Provide program/project management expertise and support to advance Tr1X's Tr1, CAR-Tr1 and in vivo cell therapy programs. Provide program management of one or more highly complex R&D programs and/or high-profile partnerships. Communicate with project team members, management leadership team, department heads, and key stakeholders including KOLs. Track and monitor key milestones and decision points to drive delivery of project objectives. Develop and refine tools for project governance and program timelines, as well as the communication of program KPIs, risks and achievements. Manage the interfaces between cross-functional teams and ensure effective handoff and communication between department functions. Lead cross-functional program management activities supporting autoimmune clinical development programs. Develop and maintain integrated clinical development plans, timelines, milestones, budgets, and risk management strategies across multiple functional areas. Partner with Clinical and senior leadership to support development strategy, indication prioritization, and pipeline programming. Ensure program activities support regulatory milestones including INDs, protocol amendments, health authority interactions, and potential BLA/MAA submissions. Partner with Clinical Operations to proactively identify enrollment, operational, and site-performance risks and implement mitigation strategies to ensure on time and on budget study recruitment. Ensure seamless coordination between…