Head of Systems Engineering
Cellanome · San Diego, CA · United States · On-site
Pay: USD 230,000 – 270,000 a year
Posted Sep 5, 2026
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We’re a well-funded start-up . You’ll get a chance to wear many hats, be a part of a growing team, and have the potential for exciting financial and career growth.
Here’s what sets us apart. We’ve set our sights on some of the biggest challenges facing biology today. We’re amassing a world class team of engineers, scientists, team builders and problem solvers to tackle these challenges heads-on. We’re passionate about developing the next generation technologies that will unravel the complexities of biology.
This is a unique opportunity to build, be part of an exciting start-up and be surrounded by good humans who are super capable, humble and down-to- earth.
We are seeking a hands-on leader for our Head of Systems Engineering to own the system architecture, technical budgets, and system-level verification and validation for the R3200 instrument platform, from current production configurations through the next generation architecture. This role reports to the SVP of Product Development and is a member of the Product Development leadership team. The person in this seat will define how the discipline operates, expands the team that runs it, and be accountable for whether our platforms meets their specifications and whether those specifications reflect what customers actually need.
Essential Duties include but are not limited to the following:
Create and own system models, define technical budgets, and use these tools to guide system and sub-system architecture decisions and manage tradeoffs.
Develop and implement system and subsystem level interfaces, test strategies and plans.
Drive fundamental understanding of complex systems which bring together hardware, consumables, chemistry, complex assays, analysis, bioinformatics, and cell biology.
Leverage insights of system fundamentals to improve performance, and to architect next generation systems.
Own system-level verification and validation strategy, including protocol definition, execution oversight, and the supporting documentation that carries the platform through phase-gate reviews.
Drive design transfer to manufacturing, partnering with Operations, suppliers, and contract manufacturers to move systems from prototype through pilot builds to volume production, including process capability and yield improvement.
Partner with technical leaders and executive leadership to prioritize R&D initiatives and guide product roadmaps.
Hold make versus buy authority for subsystem development. Select and manage external design houses and specialty suppliers.
Define statements of work, technical acceptance criteria, and milestone structures for third party development. Approve or reject deliverable acceptance.
Own the bill of materials cost target from the systems side and drive the cost reduction roadmap with Operations and Supply Chain through component consolidation, tolerance relaxation where the error budget allows, and design simplification.
Own the system…