Postdoctoral Research Fellow - Wet Lab - Ghobrial Lab

The lab of Dr. Irene Ghobrial is seeking a highly motivated Postdoctoral Research Fellow to conduct laboratory-based research and lead projects focusing on multiple myeloma and its precursor conditions. Based on the mission of the Ghobrial lab, the successful candidate will be responsible for identifying novel biomarkers for tumor burden, tumor biology, and immune state aiming to improve prognostication and monitoring of therapy response in patients with precursor conditions, including monoclonal gammopathy of unknown significance (MGUS) and smoldering multiple myeloma (SMM). In pursuit of these goals, the successful applicant will leverage next-generation technologies and advanced laboratory methods, including scRNA-seq, single-cell genomic characterization, spatial proteomics/transcriptomics, proteomics, flow sorting, and immunohistochemistry among others. In addition, the application and integration of stat-of-the-art genomic, spatial, and proteomic technologies will be key components of the effort, with particular focus on understanding the function of immune cells as key regulators of the tumor microenvironment. The work will largely involve human tissues and samples for in vitro studies and modeling, with some potential animal work. Beyond fundamental research, there is also strong interest in leveraging emerging data for drug discovery in the context of the larger DFCI ecosystem. The successful candidate will be highly organized, a team player, and able to work flexible hours to accommodate experimental needs. We are looking for a bright, motivated, and dedicated individual with strong scientific, organizational, and interpersonal skills. This post-doctoral position is available to start at any time. Interested applicants should upload their CV, and a cover letter summarizing training, publications, and future research interests, as one single PDF Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.   Qualifications Ph.D. in a biology-related field or M.D. with at least 2-3 years of laboratory experience. Strong background in cancer biology and/or immunology, ideally (but not necessarily) with a focus on the hematopoietic system, with demonstrated contributions to the field. Technical proficiency in relevant wet-laboratory techniques, including single-cell, spatial, genomic, transcriptomic,…