Scientist/Sr. Scientist, Protein Purification

Does it excite you to be the go-to purification expert delivering high-purity samples for cutting-edge structural biology and mass spec studies? If this sounds like you, and you are ready to bring deep purification expertise to a new discovery organization, then you could be our new colleague. Your new position As a Scientist or Senior Scientist in Protein Purification and Analysis, you will play an important scientific role supporting discovery programs, with a primary emphasis on high-quality purification of protein-based therapeutics and their bioconjugates. You will work hands-on with a broad range of modern protein purification technologies, with complementary analytical characterization, at the inception of our new Cambridge, MA research center. This role suits a scientist with deep, hands-on expertise in protein and bioconjugate purification, scientific curiosity, and a desire to grow in scope and responsibility. We offer exciting responsibilities: Serve as a primary supplier of high-purity protein and bioconjugate samples formatted to meet the requirements of downstream mass spectrometry (e.g., native MS, HDX-MS) and structural biology methods (e.g., cryo-EM, X-ray crystallography) Execute and support purification of recombinant proteins, peptides, and their bioconjugates (e.g., ADCs, AOCs) to support discovery programs from early research through lead-series selection Apply a broad range of purification techniques, including SEC, IEX, affinity, RP-HPLC, and CE-based methods, at analytical and preparative scales Support purification and characterization of challenging targets and formats, such as membrane proteins (e.g., GPCRs), in vitro-reconstituted target complexes, and peptide-Fc or lipidated conjugates Support analytical characterization to confirm identity, purity, concentration, and stability using mass spectrometry, chromatographic, biophysical, and flow cytometry-based methods Contribute to the development and optimization of automated and high-throughput purification workflows, improving speed, reproducibility, and data quality Your profile You bring deep, hands-on purification expertise and scientific curiosity, with a strong conceptual understanding of protein biophysics and stability principles. You thrive in a collaborative, multidisciplinary environment and are motivated to help shape purification workflows and a new research center from an early stage. You communicate scientific data, methods, and assumptions clearly and work effectively across cross-functional project teams. PhD in Analytical Chemistry, Protein Engineering, Biochemistry, or a related field preferred (postdoctoral training preferred); candidates with a BS/MS and significantly more relevant industry experience will also be considered 2+ years of relevant post-degree experience in protein purification (Scientist); 4+ years (Senior Scientist) Deep, hands-on expertise in protein and peptide purification, including SEC, IEX, affinity, RP-HPLC, and…