Scientist/Sr. Scientist Yeast Surface Dislay

Does it excite you to work at the frontier of antibody and binder discovery, and do you have hands-on experience with yeast surface display technology? If this sounds like you, and you are ready to help build a new discovery platform from the ground up, then you could be our new colleague. Your new position As a Scientist or Senior Scientist in Yeast Surface Display, you will play a central scientific role in our new Molecular Platform Development organization, driving antibody, VHH, and other mini-protein and binder discovery through yeast display technology. You will help build and operate a modern, high-throughput display platform at the inception of our new Cambridge, MA research center. This role suits a scientist with strong technical expertise across the full yeast surface display workflow, scientific curiosity, and a desire to grow in scope and responsibility. We offer exciting responsibilities: Execute the full yeast surface display workflow, from library construction and transformation through magnetic bead and FACS-based selections, generating antibody, VHH, affibody, constrained peptide, and other mini-protein binders Conduct display selections against complex and challenging targets, including GPCRs, other multi-pass membrane proteins, and receptor complexes Design and execute affinity maturation and selection strategies to improve binder affinity, specificity, and developability Apply next-generation sequencing (NGS) to track library diversity, monitor selection enrichment, and identify lead clones from display campaigns Contribute to the development and application of yeast surface display capabilities within Molecular Platform Development Partner closely with Mass Spectrometry, Biophysics, and Pharmaceutical Development colleagues to validate hit quality, sequence fidelity, and developability early in selection campaigns Your profile You bring strong technical expertise across the full yeast surface display workflow, along with scientific curiosity and sound judgment. You thrive in a collaborative, multidisciplinary environment and are motivated to help shape a new platform and research center from an early stage. You communicate scientific data and concepts clearly and work effectively across cross-functional project teams. PhD in Protein Engineering, Immunology, Molecular Biology, Biochemistry, or a related field preferred (postdoctoral training preferred); candidates with a BS/MS and significantly more relevant industry experience will also be considered 2+ years of relevant post-degree experience in yeast surface display or related antibody/protein discovery technologies (Scientist); 4+ years (Senior Scientist) Experience with antibody, VHH, affibody, constrained peptide, and other mini-protein or binder formats Experience conducting display selections against complex targets, such as GPCRs, other multi-pass membrane proteins, or receptor complexes, is a plus Experience applying next-generation sequencing (NGS)…