Senior Downstream Process Engineer

About Nūmi 🚀 Nūmi is a bioproduction platform harnessing human mammary cells to produce key ingredients with proven health benefits across all stages of life. More specifically, it is the first European cultivated breast milk company aiming to produce human milk constituents to better match the ideal nutrition for babies. We are an early-stage, VC-backed biotech based in the heart of Paris (Hôpital Cochin, Paris 14th) and supported by world-class investors and scientific partners. ⚖️ Nūmi's Values ☀️ Positivity : At Nūmi, we cultivate positivity every day. Our mission drives us to communicate with passion and energy, always keeping the bigger impact in sight. We celebrate quick wins, but never lose track of our ultimate goal. 🤸 Excellence : At Nūmi, excellence starts with dedication and a commitment to constant improvement. We embrace challenges as opportunities to learn and push ourselves to deliver high-quality results. Through effort, attention to detail, and integrity, we grow both individually and collectively as a team. 💙 Team-Work and Pedagogy : At Nūmi, we believe that teamwork makes us stronger. We encourage knowledge-sharing, open feedback, and mutual respect. Each Nūmiz is here to lift others up, ensuring that the collective succeeds. 🚀 Ambition : At Nūmi, we set ambitious goals and challenge ourselves to think big. Nūmi is driven by bold ideas and relentless determination, always aiming for the stars to create real impact. Why this role matters 🌟 As Nūmi scales its ingredient portfolio (proteins, human milk oligosaccharides, functional lipids) from bench through pilot to first industrial batches, we are looking for a Senior Downstream Process Engineer to own our purification strategy hands-on. Reporting to our Head of Industrialisation and working closely with our Head of USP, our Reg & QC Implementation Lead and our CMC Lead, you will be the senior technical anchor for our DSP function, and you will mentor a team of DSP Engineers. This is a role for someone who has spent a decade or more purifying complex biomolecules from fermentation broths, cell culture supernatants or milk fractions, and who now wants to build a first-of-its-kind DSP platform from the ground up. Key Responsibilities 🧪 Own the DSP Strategy and Roadmap Define and deliver Nūmi's downstream process strategy across the ingredient portfolio (proteins, oligosaccharides, functional lipids). Own the DSP scale-up trajectory from lab scale through pilot and toward first industrial batches. Design and refine unit-operation sequences (clarification, capture, intermediate purification, polishing, formulation, drying) tuned to each ingredient. ⚗️ Lead Hands-On Process Development Design, execute and interpret experiments on chromatography (ion exchange, affinity, hydrophobic interaction, size exclusion, simulated moving bed), membrane operations (MF, UF, DF, TFF, nanofiltration), centrifugation, precipitation, spray or freeze drying. Apply DoE and…