Sr. Software Engineer, Clinical Software

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Summary: We are seeking a Sr. Software Engineer to design, develop, and maintain our Laboratory Information Management Systems (LIMS). This role is a key contributor to our engineering team, taking ownership of feature development for both existing systems and new cloud-based platforms. You will work with senior engineers to tackle complex problems and deliver high-quality, scalable solutions that power our laboratory operations in a regulated environment. Onsite: Monday, Tuesday, and Thursday Responsibilities: Design, develop, test, and maintain software systems and features supporting laboratory operations. Develop and optimize backend services and APIs using Python and/or Java. Implement solutions using a variety of database technologies, including relational and graph databases. Take ownership of deploying and maintaining services in our AWS cloud environment. Actively participate in code reviews, design discussions, and technical documentation to ensure quality and maintainability. Troubleshoot and resolve complex technical issues in development and production environments. Collaborate with cross-functional teams to translate business requirements into robust technical solutions. Qualifications: B.S. degree in Computer Science, Engineering, or a related technical field. 5 years of professional software development experience. Strong proficiency in at least one programming language such as Python or Java. Proven experience building and deploying applications on AWS. Solid experience with relational databases (e.g., PostgreSQL, MySQL) and developing REST APIs. Experience with version control systems (e.g., Github, Bitbucket) and CI/CD concepts. Excellent problem-solving skills and the ability to work independently on complex tasks. Preferred: Experience with web frameworks like Flask or FastAPI. Familiarity with modern JavaScript frameworks (e.g., React, Angular, or Vue.js). Experience in the life sciences, healthcare, or another regulated industry. Familiarity with containerization technologies (e.g., Docker). Exposure to graph databases or NoSQL technologies. What You’ll Gain Opportunity to take ownership of significant features and projects from design to deployment. Deepen your expertise in AWS services and cloud…