Sr. Systems Engineer (Onsite Support)

COMPANY: At BioCryst, we share a deep commitment to improving the lives of people living with hereditary angioedema (HAE) and other rare diseases. We leverage our expertise in structure-guided drug design to develop first-in-class or best-in-class oral small-molecule and injectable protein therapeutics. Our global headquarters is in Durham, North Carolina, we have a regional office in Boston, Massachusetts, and our employees span the globe across sites in multiple countries. We are proud of our culture of engagement and accountability that rewards people for innovative thinking and achievement of key objectives. For more information, please visit our website at www.biocryst.com  or follow us   on LinkedIn  and Instagram . JOB SUMMARY: BioCryst is a fast-growing pharmaceutical company seeking an experienced Sr. Systems Engineer to support and manage the company's Microsoft cloud services, including Microsoft 365, Azure, Exchange Online, SharePoint Online, Teams, Entra ID, and related security and compliance technologies. The role will also provide operational support for on-premises infrastructure at the Durham location, including networking, wireless, switching, internet connectivity, and data center technologies. The successful candidate will ensure enterprise systems remain secure, reliable, compliant, and aligned with the company's technology strategy. Please note, this role is NOT remote and you will be required to work in the office 5 days a week. ESSENTIAL DUTIES & RESPONSIBILITIES: Design, administer, support, and optimize Microsoft enterprise cloud platforms and services, including Microsoft 365, Azure, SharePoint Online, Exchange Online, Teams, Purview, and Entra ID. Provide operational support and lead the evaluation, testing, and rollout of new features and service enhancements while ensuring platform availability, performance, reliability, and user adoption. Serve as the technical owner for Microsoft enterprise cloud platforms and services, establishing standards, evaluating new capabilities, and ensuring solutions align with business, operational, security, and compliance requirements. Architect and deliver solutions that address business and operational needs, serving as the technical lead for the successful implementation of technology initiatives and process improvements while managing multiple priorities and projects. Administer and support on-premises infrastructure at the Durham location, including networking, wireless, switching, internet connectivity, firewalls, and related infrastructure systems. Participate in after-hours maintenance and support activities as required. Provide onsite infrastructure support five days per week within the Durham office location. Partner with the company's managed service providers (MSPs) to monitor, maintain, and troubleshoot cloud and infrastructure services, ensuring performance, availability, and reliability while supporting server, backup, and disaster recovery platforms…