Staff Bioinformatics Scientist

At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives.   We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting-edge molecular science and AI, we ask ourselves every day:   “What would I do if this patient were my mom?”   That question drives everything we do.   But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose.   Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins. Position Summary The Staff Bioinformatics Scientist leads a team of bioinformatics scientists responsible for the development, validation, implementation, and support of next-generation sequencing (NGS) bioinformatics pipelines and analytical workflows within a clinical or translational genomics environment. This role combines technical expertise, project leadership, and people management to ensure delivery of reliable, scalable, and compliant bioinformatics solutions supporting research, assay development, validation activities, and clinical operations. This role partners closely with laboratory, clinical, software engineering, IT, quality, and scientific stakeholders to advance genomic testing capabilities and operational excellence. Job Responsibilities Lead, coach, mentor, and develop a team of bioinformatics scientists, including hiring support, onboarding, performance management, career development, and workload prioritization. Manage day-to-day bioinformatics operations and ensure timely delivery of high-quality analytical solutions across development, validation, and production activities. Establish project plans, priorities, timelines, and resource allocations for team initiatives and cross-functional programs. Oversee development, optimization, validation, and maintenance of NGS bioinformatics pipelines and workflows. Support end-to-end genomic data analysis, including quality control, alignment, variant calling, annotation, filtering, interpretation support, and reporting workflows. Lead analytical development and validation activities for NGS assays, including performance assessment, reproducibility studies, concordance analysis, quality metrics, and documentation. Drive implementation of scalable, automated, and reproducible computational workflows using software development and bioinformatics best practices. Collaborate with software engineering and IT teams to support cloud-based infrastructure, workflow execution, data storage, monitoring, and system performance. Ensure bioinformatics processes comply with applicable quality, regulatory,…